Characterization of High-Molecular-Mass Forms of Basic Fibroblast Growth Factor Produced by Hepatocellular Carcinoma Cells: Possible Involvement of Basic Fibroblast Growth Factor in Hepatocarcinogenesis
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چکیده
منابع مشابه
High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.
A 6.75-kilobase human hepatoma-derived basic fibroblast growth factor (bFGF) cDNA was cloned and sequenced. An amino-terminal sequence generated from a purified hepatoma bFGF was found to correspond to the nucleotide sequence and to begin 8 amino acids upstream from the putative methionine start codon thought to initiate a 154-amino acid bFGF translation product. This sequence suggests that a f...
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Basic fibroblast growth factor (bFGF) may act to modulate hematopoiesis in addition to its effects on mesenchymal cells. We studied the effects of bFGF on human and murine primary marrow megakaryocytes. bFGF modestly enhanced the size of the human megakaryocyte colony-forming unit (CFU-MK) and cell numbers per colony, in combination with interleukin-3 (IL-3) or granulocyte-macrophage colony sti...
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To increase our understanding of the potential role of basic fibroblast growth factor (bFGF) in malignant progression of prostate cancer, we determined the production of bFGF, the expression of FGF receptor (flg), and the response to exogenous bFGF in LNCaP, DU 145, and PC 3 cells. We observed that these three prostate cancer cell lines, which differed in their dependence on androgens for growt...
متن کاملThe clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma.
Heparan sulfate plays an essential role for insolubility of the components of extracellular matrix and represents a storage depot for various growth factors. Therefore, heparanase produced by a given tumor may facilitate tumor invasiveness and angiogenesis through the release of heparan sulfate-bound growth factors. Although the growth factors responsible for angiogenesis in hepatocellular carc...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1991
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1991.tb01791.x